Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

نویسندگان

  • Y. Iturria-Medina
  • R. C. Sotero
  • P. J. Toussaint
  • J. M. Mateos-Pérez
  • A. C. Evans
  • Michael W. Weiner
  • Paul Aisen
  • Ronald Petersen
  • Clifford R. Jack
  • William Jagust
  • John Q. Trojanowki
  • Arthur W. Toga
  • Laurel Beckett
  • Robert C. Green
  • Andrew J. Saykin
  • John Morris
  • Leslie M. Shaw
  • Zaven Khachaturian
  • Greg Sorensen
  • Lew Kuller
  • Marc Raichle
  • Steven Paul
  • Peter Davies
  • Howard Fillit
  • Franz Hefti
  • Davie Holtzman
  • M Marcel Mesulam
  • William Potter
  • Peter Snyder
  • Adam Schwartz
  • Tom Montine
  • Ronald G. Thomas
  • Michael Donohue
  • Sarah Walter
  • Devon Gessert
  • Tamie Sather
  • Gus Jiminez
  • Danielle Harvey
  • Matthew Bernstein
  • Nick Fox
  • Paul Thompson
  • Norbert Schuff
  • Bret Borowski
  • Jeff Gunter
  • Matt Senjem
  • Prashanthi Vemuri
  • David Jones
  • Kejal Kantarci
  • Chad Ward
  • Robert A. Koeppe
  • Norm Foster
  • Eric M. Reiman
  • Kewei Chen
  • Chet Mathis
  • Susan Landau
  • Nigel J. Cairns
  • Erin Householder
  • Lisa Taylor-Reinwald
  • Virginia Lee
  • Magdalena Korecka
  • Michal Figurski
  • Karen Crawford
  • Scott Neu
  • Tatiana M. Foroud
  • Steven Potkin
  • Li Shen
  • Kelley Faber
  • Sungeun Kim
  • Kwangsik Nho
  • Leon Thal
  • Neil Buckholtz
  • Marylyn Albert
  • Richard Frank
  • John Hsiao
  • Jeffrey Kaye
  • Joseph Quinn
  • Betty Lind
  • Raina Carter
  • Sara Dolen
  • Lon S. Schneider
  • Sonia Pawluczyk
  • Mauricio Beccera
  • Liberty Teodoro
  • Bryan M. Spann
  • James Brewer
  • Helen Vanderswag
  • Adam Fleisher
  • Judith L. Heidebrink
  • Joanne L. Lord
  • Sara S. Mason
  • Colleen S. Albers
  • David Knopman
  • Kris Johnson
  • Rachelle S. Doody
  • Javier Villanueva-Meyer
  • Munir Chowdhury
  • Susan Rountree
  • Mimi Dang
  • Yaakov Stern
  • Lawrence S. Honig
  • Karen L. Bell
  • Beau Ances
  • Maria Carroll
  • Sue Leon
  • Mark A. Mintun
  • Stacy Schneider
  • Angela Oliver
  • Daniel Marson
  • Randall Griffith
  • David Clark
  • David Geldmacher
  • John Brockington
  • Erik Roberson
  • Hillel Grossman
  • Effie Mitsis
  • Leyla de Toledo-Morrell
  • Raj C. Shah
  • Ranjan Duara
  • Daniel Varon
  • Maria T. Greig
  • Peggy Roberts
  • Marilyn Albert
  • Chiadi Onyike
  • Daniel D'Agostino
  • Stephanie Kielb
  • James E. Galvin
  • Brittany Cerbone
  • Christina A. Michel
  • Henry Rusinek
  • Mony J. de Leon
  • Lidia Glodzik
  • Susan De Santi
  • P. Murali Doraiswamy
  • Jeffrey R. Petrella
  • Terence Z. Wong
  • Steven E. Arnold
  • Jason H. Karlawish
  • David Wolk
  • Charles D. Smith
  • Greg Jicha
  • Peter Hardy
  • Partha Sinha
  • Elizabeth Oates
  • Gary Conrad
  • Oscar L. Lopez
  • MaryAnn Oakley
  • Donna M. Simpson
  • Anton P. Porsteinsson
  • Bonnie S. Goldstein
  • Kim Martin
  • Kelly M. Makino
  • M. Saleem Ismail
  • Connie Brand
  • Ruth A. Mulnard
  • Gaby Thai
  • Catherine Mc-Adams-Ortiz
  • Kyle Womack
  • Dana Mathews
  • Mary Quiceno
  • Ramon Diaz-Arrastia
  • Richard King
  • Myron Weiner
  • Kristen Martin-Cook
  • Michael DeVous
  • Allan I. Levey
  • James J. Lah
  • Janet S. Cellar
  • Jeffrey M. Burns
  • Heather S. Anderson
  • Russell H. Swerdlow
  • Liana Apostolova
  • Kathleen Tingus
  • Ellen Woo
  • Daniel H. S. Silverman
  • Po H. Lu
  • George Bartzokis
  • Neill R. Graff-Radford
  • Francine Parfitt
  • Tracy Kendall
  • Heather Johnson
  • Martin R. Farlow
  • AnnMarie Hake
  • Brandy R. Matthews
  • Scott Herring
  • Cynthia Hunt
  • Christopher H. van Dyck
  • Richard E. Carson
  • Martha G. MacAvoy
  • Howard Chertkow
  • Howard Bergman
  • Chris Hosein
  • Sandra Black
  • Bojana Stefanovic
  • Curtis Caldwell
  • Ging-Yuek Robin Hsiung
  • Howard Feldman
  • Benita Mudge
  • Michele Assaly
  • Andrew Kertesz
  • John Rogers
  • Charles Bernick
  • Donna Munic
  • Diana Kerwin
  • Marek-Marsel Mesulam
  • Kristine Lipowski
  • Chuang-Kuo Wu
  • Nancy Johnson
  • Carl Sadowsky
  • Walter Martinez
  • Teresa Villena
  • Raymond Scott Turner
  • Kathleen Johnson
  • Brigid Reynolds
  • Reisa A. Sperling
  • Keith A. Johnson
  • Gad Marshall
  • Meghan Frey
  • Barton Lane
  • Allyson Rosen
  • Jared Tinklenberg
  • Marwan N. Sabbagh
  • Christine M. Belden
  • Sandra A. Jacobson
  • Sherye A. Sirrel
  • Neil Kowall
  • Ronald Killiany
  • Andrew E. Budson
  • Alexander Norbash
  • Patricia Lynn Johnson
  • Joanne Allard
  • Alan Lerner
  • Paula Ogrocki
  • Leon Hudson
  • Evan Fletcher
  • Owen Carmichael
  • John Olichney
  • Charles DeCarli
  • Smita Kittur
  • Michael Borrie
  • T-Y Lee
  • Rob Bartha
  • Sterling Johnson
  • Sanjay Asthana
  • Cynthia M. Carlsson
  • Steven G. Potkin
  • Adrian Preda
  • Dana Nguyen
  • Pierre Tariot
  • Stephanie Reeder
  • Vernice Bates
  • Horacio Capote
  • Michelle Rainka
  • Douglas W. Scharre
  • Maria Kataki
  • Anahita Adeli
  • Earl A. Zimmerman
  • Dzintra Celmins
  • Alice D. Brown
  • Godfrey D. Pearlson
  • Karen Blank
  • Karen Anderson
  • Robert B. Santulli
  • Tamar J. Kitzmiller
  • Eben S. Schwartz
  • Kaycee M. Sink
  • Jeff D. Williamson
  • Pradeep Garg
  • Franklin Watkins
  • Brian R. Ott
  • Henry Querfurth
  • Geoffrey Tremont
  • Stephen Salloway
  • Paul Malloy
  • Stephen Correia
  • Howard J. Rosen
  • Bruce L. Miller
  • Jacobo Mintzer
  • Kenneth Spicer
  • David Bachman
  • Elizabether Finger
  • Stephen Pasternak
  • Irina Rachinsky
  • Dick Drost
  • Nunzio Pomara
  • Raymundo Hernando
  • Antero Sarrael
  • Susan K. Schultz
  • Laura L. Boles Ponto
  • Hyungsub Shim
  • Karen Elizabeth Smith
  • Norman Relkin
  • Gloria Chaing
  • Lisa Raudin
  • Amanda Smith
  • Kristin Fargher
  • Balebail Ashok Raj
  • Thomas Neylan
  • Jordan Grafman
  • Melissa Davis
  • Rosemary Morrison
  • Jacqueline Hayes
  • Shannon Finley
  • Karl Friedl
  • Debra Fleischman
  • Konstantinos Arfanakis
  • Olga James
  • Dino Massoglia
  • J. Jay Fruehling
  • Sandra Harding
  • Elaine R. Peskind
  • Eric C. Petrie
  • Gail Li
  • Jerome A. Yesavage
  • Joy L. Taylor
  • Ansgar J. Furst
چکیده

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD-abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions.

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2016